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Silica Supported Polyphosphoric Acid Catalyzed Synthesis of Substituted Indazoles

Year: 2019

Type: article

Abstract: A clean and straightforward methodology developed for the synthesis of substituted indazoles using silica supported polyphosphoric acid (PPA-SiO 2 ) catalyzed condensation reaction between substituted 2-hydroxybenzaldehydes or acetophenones and hydrazine hydrate or phenylhydrazine. The reaction conditions are optimized for different solvents at different temperatures. The yield of the products improved to 88 to 90 % using silica supported polyphosphoric acid as a catalyst, which is reusable, cost-effective and straightforward to synthesize.

Source: European Chemical Bulletin

DOI: 10.17628/ecb.2019.8.137-140

Authors: Santosh Vikram Raut, Bharat K. Dhotre, Shivshanklar P. More, Atul D. Tidke, Mohd Arif Ali Khan Pathan

Language: English

Topic: Multicomponent Synthesis of Heterocycles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $107

OpenAlex ID: W2946902027

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