Work

The role of interleukin-1 in general pathology

Year: 2019

Type: review

Abstract: Interleukin-1, an inflammatory cytokine, is considered to have diverse physiological functions and pathological significances and play an important role in health and disease. In this decade, interleukin-1 family members have been expanding and evidence is accumulating that highlights the importance of interleukin-1 in linking innate immunity with a broad spectrum of diseases beyond inflammatory diseases. In this review, we look back on the definition of "inflammation" in traditional general pathology and discuss new insights into interleukin-1 in view of its history and the molecular bases of diseases, as well as current progress in therapeutics.

Source: Inflammation and Regeneration

DOI: 10.1186/s41232-019-0101-5

Authors: Naoe Kaneko, Mie Kurata, Toshihiro Yamamoto, Shinnosuke Morikawa, Junya Masumoto

Institutions: Ehime University, Proteo-Science Center, Ehime University

Language: English

Topic: Inflammasome and immune disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $993