Work

SNA-8073-B, a New Isotetracenone Antibiotic Inhibits Prolyl Endopeptidase. I. Fermentation, Isolation and Biological Properties.

Year: 1997

Type: article

Abstract: SNA-8073-B, an inhibitor of prolyl endopeptidase isolated from the broth filtrate of Streptomyces sp. SNA-8073, is a new isotetracenone antibiotic. It was purified by ethyl acetate extraction, silica gel column chromatography and high performance liquid chromatography on ODS column. SNA-8073-B has the molecular formula of C20H16O5 and is a stereoisomer of SNA-8073-A (fujianmycin B, rubiginone A2). SNA-8073-B inhibited prolyl endopeptidase of Flavobacterium non-competitively (IC50 = 8.9 microM) when Z-Gly-Pro-pNA was used as a substrate, but SNA-8073-A did not show any inhibition even at 60 microM.

Source: The Journal of Antibiotics

DOI: 10.7164/antibiotics.50.291

Authors: KEN-ICHI KIMURA, FUMIKO KANOU, HIROYUKI KOSHINO, MASAKAZU URAMOTO, MAKOTO YOSHIHAMA

Institutions: Megmilk Snow Brand (Japan), RIKEN, Tamagawa University

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Applied Microbiology and Biotechnology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W2949908459

FWCI: 1.992

Cites: 26

Cited by: 21

Related to: 10