Work

Biological Evaluation of 2-Aryl-2-fluoropropionic Acids as Possible Platforms for New Medicinal Agents

Year: 2005

Type: article

Abstract: We investigated the cyclooxygenase (COX) inhibitory and anticancer activities of 2-aryl-2-fluoropropionic acids 1a-e. These fluorinated compounds showed lower inhibitory activity toward COX-1 than the corresponding non-fluorinated compounds 2a-e with retained inhibitory activity against COX-2 resulting in modification of the balance of COX-1/COX-2 inhibitions, and they showed little anticancer activity. Interesting differences of the activities between (S)- and (R)-enantiomers were observed in some cases.

Source: Chemical and Pharmaceutical Bulletin

DOI: 10.1248/cpb.53.1062

Authors: Yoshio Takeuchi, Hidehito Fujisawa, Tomoya Fujiwara, Mamoru Matsuura, Hirotsugu Komatsu, Satoshi Ueno, Takeshi Matsuzaki

Institutions: University of Toyama, Mitsubishi Group (Japan), Yakult Central Institute

Language: English

Topic: Inflammatory mediators and NSAID effects

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2951754364

FWCI: 0.765

Cites: 14

Cited by: 18

Related to: 10