MR-387A and B, New Aminopeptidase N Inhibitors, Produced by Streptomyces neyagawaensis SL-387.
Year: 1996
Type: article
Abstract: Aminopeptidase N (AP-N, or aminopeptidase M, EC 3.4.ll.2) is a memberof a family of membrane-bound metallopeptidases with wide distribution on the surfaces of diverse cell types.X) This enzyme plays the part of an enzymewhich inactivates enkephalins, the pentapetides with morphine-like activities in cerebral membranes.2)In recent years, the human myeloid plasma membrane glycoprotein CD13has been proved to be identical to AP-N,3) and it is expressed in human myeloid leukemia cell lines4) and malignant mesenchymal tumors.5)Saiki et al.6) and Menrad et al.1] have found aminopeptidase N to play important roles in the invasion of metastatic tumors in vitro.Recently, Ino et al.8) also suggested that AP-Ninhibitors such as bestatin and actinonin couldbecome new drugs for cancer treatment, not as biological response modifiers (BRM), but as anti-cancer chemicals exerting direct suppressive action on the growth or metastasis of certain cancers.Thus, the specific inhibition ofAP-N could be a new approach to suppress the growth or metastasis of cancer.During the screening for new inhibitors of aminopeptidase N, we obtained new substances MR-387Aand B (Fig. 1) from the culture broth of Streptomyces neyagawaensis SL-387.In this communication, we report 99 the isolation, physico-chemical properties, structure elucidation and biological activities of the inhibitors.Strain SL-387 was isolated from a soil sample collected in the province of Wolchoolsan National Park, Chullanam-do, Korea.This strain was identified by taxonomiccharacterization as a strain of Streptomyces neyagawaensis.9)It has been deposited in the Korean
Source: The Journal of Antibiotics
Language: English
Subfield: Pharmacology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2953179072