Work

Phenotypic Plasticity as a Strategy of Bacterial Resistance and an Object of Advanced Antimicrobial Technologies (Review)

Year: 2019

Type: article

Abstract: Adaptation to continuously changing habitat is one of the most important characteristics of microorganisms.A particularly effective form of adaptation is called phenotypic plasticity.This ability allows bacteria with a stable genotype to create different phenotypes in response to environmental changes.Such variability is not inheritable but is crucial for maintaining this specific bacterial population and, even more, for developing resistanc e to antibiotics.Studying the phenotypic plasticity, which underlies the resistance of microorganisms to traditional antibiotic therapy, is a key area of the current antimicrobial technologies.In this review, phenotypic plasticity is considered to be a strategy of bacterial survival and a mechanism for developing antibiotic resistance in dormant (resistant) cellular forms of bacteria.We suggest that studying the phenotypic variants of bacteria (L-forms; viable but nonculturable bacteria; persister cells) will result in the development of novel effective antimicrobial technologies.

Source: Современные технологии в медицине

DOI: 10.17691/stm2019.11.2.22

Authors: B.G. Andryukov, L.M. Somova, E.V. Matosova, I.N. Lyapun

Institution: Far Eastern Federal University

Language: English

Topic: Bacterial Genetics and Biotechnology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Russian Academy of Sciences