Work

Exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo–keto reductase 1C3 target affinity

Year: 2019

Type: article

Abstract: Tetrahydroisoquinoline (THIQ) is a key structural component in many biologically active molecules including natural products and synthetic pharmaceuticals. Here, we report on the use of transition-metal mediated [2 + 2 + 2] cyclotrimerisation of alkynes to generate tricyclic THIQs with potential to selectively inhibit AKR1C3.

Source: MedChemComm

DOI: 10.1039/c9md00201d

Authors: Ana R. N. Santos, Helen M. Sheldrake, Ali I. M. Ibrahim, Chhanda Charan Danta, Davide Bonanni, Martina Daga, Simonetta Oliaro-Bosso, Donatella Boschi, Marco L. Lolli, Klaus Pors

Institutions: University of Bradford, University of Turin

Language: English

Topic: Catalytic Alkyne Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: Fondazione CRT, Research Councils UK, Università degli Studi di Torino, Engineering and Physical Sciences Research Council, Fundação para a Ciência e a Tecnologia

Awards: G5560724896, G7658723419, DEVELOPMENT OF NEW METHODOLOGIES TO SYNTHESISE BIOLOGICALLY ACTIVE TETRAHYDROISOQUINOLINES

OpenAlex ID: W2953544211

FWCI: 0.28

Cites: 24

Cited by: 4

Related to: 10