Work

NU-6027 Inhibits Growth of Mycobacterium tuberculosis by Targeting Protein Kinase D and Protein Kinase G

Year: 2019

Type: article

Abstract: Tuberculosis (TB) is a global health concern, and this situation has further worsened due to the emergence of drug-resistant strains and the failure of BCG vaccine to impart protection. There is an imperative need to develop highly sensitive, specific diagnostic tools, novel therapeutics, and vaccines for the eradication of TB. In the present study, a chemical screen of a pharmacologically active compound library was performed to identify antimycobacterial compounds.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.00996-19

Authors: Saqib Kidwai, Rania Bouzeyen, Sohini Chakraborti, Neha Khare, Sumana Das, Tannu Priya Gosain, Assirbad Behura, Chhuttan Lal Meena, Rohan Dhiman, Makram Essafi, Avinash Bajaj, Deepak Kumar Saini, Narayanaswamy Srinivasan, Dinesh Mahajan, Ramandeep Singh

Institutions: Translational Health Science and Technology Institute, Institut Pasteur de Tunis, Tunis El Manar University, Indian Institute of Science Bangalore, Regional Centre for Biotechnology, National Institute of Technology Rourkela

Language: English

Topic: Tuberculosis Research and Epidemiology

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: Department of Science and Technology, Ministry of Science and Technology, India

Awards: G4746636301, G7023221497

OpenAlex ID: W2954439699

FWCI: 3.885

Cites: 86

Cited by: 41

Related to: 10