Work

Cellular prion level in the animals’ tissues

Year: 2018

Type: article

Abstract: Prion infections cause brain damage in humans and animals with lethal outcome. Cellular prion (PrP C ) is a precursor of pathological prion. Infection development depends on the level of its production in the different tissues.Comparative data on the relative level of molecular isoforms of the cellular prion in the brain, spleen and small intestine of various animals, in particular cows, laboratory rats and mice, are demonstrated.Obtained data are important for understanding of the pathogen spreading mechanisms in the case of infection.It can be used as one of the indices for prion infection strains determination and in TSE diagnostics.

Source: Bulletin Veterinary biotechnology

DOI: 10.31073/vet_biotech32(2)-75

Authors: M. V. Kushkevych, M. R. Kozak, I. M. Petruh, V. V. Vlizlo

Institution: Institute of Animal Biology NAAS

Language: English

Topic: Prion Diseases and Protein Misfolding

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2954958151