Protective Role of Either Ginger or Lipoic Acid in Senile Female Rats
Year: 2014
Type: article
Abstract: Aging associated with neurodegenerative disorders. The dysregulation of brain lipid metabolism might contribute to the mechanisms of aging and Alzheimer's disease. The study aimed to evaluate the change in free fatty acids and free calcium ion contents, as well as the total antioxidant activity in senile female rat's brain. Moreover, the possible protective effect of either ginger or alpha lipoic acid. The experimental groups (n=6/group) administered orally for four weeks and classified into: 1- Control adult female rats group and 2- Senile female group (both groups) received one ml/100 g b.wt. 0.5 g/100 ml CMC. 3- Senile ginger group received 250 mg/kg ginger. 4- Senile lipoic treated group administered 65 mg/kg lipoic acid. The results suggested protective effect of ginger and alpha lipoic acid in senile female rats through modulation of, saturated, unsaturated fatty acids and the total antioxidant capacity in cortex and hippocampus. In addition, the cortical free calcium ions content that could protect the senile rats from ageing diseases.
Source: Research in neuroscience
Authors: Nadia M. S. Arafa, Elham H. A. Ali
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W29554279