Effect of N-acetylcysteine on Hepatic Ischemiareperfusion Injury in Normal and Steatotic Rats
Year: 2011
Type: article
Abstract: Background: Liver ischemia-reperfusion (I/R) injury occurs during major liversurgery, transplantation or following haemorrhagic shock with subsequent fluidresuscitation. Liver steatosis is a risk factor in liver transplantation and liverresection. Aim: This study was undertaken to evaluate the effect of N-acetylcysteine(NAC) on hepatic I/R injury in both normal and steatotic rat livers. Material andmethods: 48 male wistar rats, divided into 2 equal groups, steatosis was induced inone of them by high cholesterol diet for 8 weeks. Each of these 2 groups wassubdivided into 3 subgroups; control, I/R, I/R+ NAC groups. At the end ofexperiment, liver enzymes, inflammatory, lipid peroxidation and oxidative parameterswere assessed and histopathological examination of liver samples was done to provethe incidence of steatosis. Results: NAC produced significant reduction in liverenzymes, inflammatory, lipid peroxidation parameters and significant increase inantioxidant parameters in both normal and steatotic rats. Conclusion: NAC may beconsidered as a promising therapeutic candidate for chemoprevention of hepatic I/Rinjury through its antioxidant, anti-inflammatory, antifibrotic, antiapoptic andantisteatotic effects in either normal or steatotic livers.
Authors: Nahid Tahoon, Ahmed Abdalfattah
Institution: Tanta University
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2961865950