Subunit contribution to NMDA receptor hypofunction and redox sensitivity of hippocampal synaptic transmission during aging
Year: 2019
Type: article
Abstract: /calmodulin-dependent protein kinase II (CaMKII). The results indicate that activity-dependent NMDAR synaptic plasticity is suppressed by redox-mediated inhibition of CaMKII activation during aging. The redox regulation of NMDARs represents a suppression of a metaplasticity mechanism, which can disrupt synaptic plasticity and cognition associated with neurological or psychiatric diseases, and aging.
Source: Aging
Institution: University of Florida
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
Awards: Estrogen and cognition over the lifespan, Signaling cascades and memory deficits during aging, G5078890819, Systemic inflammation in regulating the onset and progression of brain aging, Systemic inflammation in regulating the onset and progression of brain aging, University of Florida Older Americans Independence Center (OAIC)
OpenAlex ID: W2963321209