Study of Prevalence of Tuberculosis and Rifampicin Resistant Tuberculosis Among the Sample Received at Cb-naat Center in a Tertiary Care Hospital Anmmch, Gaya
Year: 2019
Type: article
Study design: Observational Study
Abstract: BACKGROUNDTuberculosis (TB) remains a leading health problem not only in India but all over the world.India is the country with highest TB burden accounting for one-fourth (25%) of global TB cases.Diagnosis of tuberculosis (Pulmonary and Extra Pulmonary TB) still remains a challenge.By using the traditional method for diagnosing TB like tuberculin test, chest radiography and/or sputum microscopy, the result was not so convincing.In sputum microscopy, the yield of identifying TB bacilli is very low especially in paediatric TB due to the paucibacillary nature.Thus, diagnosis of TB especially in immunocompromised patients, sputum-smear negative or paediatric cases is more problematic and challenging.By WHO in December 2010, Xpert® MTB/RIF assay (Cepheid, Sunnyvale CA, USA) was recommended, based on real-time nucleic acid amplification technology and automated.Xpert® MTB/RIF assay done with barcoded cartridge, so this technique is also called cartridge based nucleic acid amplification test (CB-NAAT).This study assessed the applicability of (Gene Xpert) in early diagnosis of TB, and early identification of MDR-TB.GeneXpert is one of the recent technological instruments used to diagnose tuberculosis in a short span of time. METHODSThis was a cross sectional study, carried out on all patients of who were suspected cases of tuberculosis, visiting the OPD or indoor at tertiary care hospital ANMMCH, Gaya, over a period of 3 months from 01-10-2017 to 31-12-2017.A total of 489 patients were sent for CB-NAAT center. RESULTSOut of 489 suspected patients, 127 (25.97%) were detected positive for MTB.Among the 127 MTB detected cases 102 (80.31%) were Rifampicin sensitive and Rifampicin resistance was 25 (19.68%). CONCLUSIONSThis study makes us aware of the high burden of tuberculosis cases and higher risk of MDR-TB in this local region.It also helps in early institution of first line anti-tubercular therapy and screening of MDR-TB for further second line anti-TB drugs therapy to get an earlier and better outcome.
Institution: Anugrah Narayan Magadh Medical College & Hospital
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2963537366