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Multi-omics Analyses Reveal Synergistic Carbohydrate Metabolism in Streptococcus mutans-Candida albicans Mixed-Species Biofilms

Year: 2019
Type: article
Abstract: Candida albicans , a major opportunistic fungal pathogen, is frequently found together with Streptococcus mutans in dental biofilms associated with severe childhood caries (tooth decay), a prevalent pediatric oral disease. However, the impact of this cross-kingdom relationship on C. albicans remains largely uncharacterized. Here, we employed a novel quantitative proteomics approach in conjunction with transcriptomic profiling to unravel molecular pathways of C. albicans when cocultured with S. mutans in mixed biofilms.
DOI: 10.1128/iai.00339-19
Authors: K. Ellepola, T. Truong, Y. Liu, Q. Lin, T. K. Lim, Y. M. Lee, T. Cao, H. Koo, C. J. Seneviratne
Institutions: National University of Singapore, Louisiana State University Health Sciences Center New Orleans, University of Pennsylvania, SingHealth, SingHealth Duke-NUS Academic Medical Centre, Duke-NUS Medical School, National Dental Centre of Singapore
Language: English
Subfield: Periodontics
Field: Dentistry
Open Access status: hybrid
OpenAlex ID: W2965166374
FWCI: 9.291
Cites: 51
Cited by: 123
Related to: 10