Work

Molecular mechanisms of lncRNAs in regulating cancer cell radiosensitivity

Year: 2019

Type: review

Abstract: Radiotherapy is one of the main modalities of cancer treatment. However, tumor recurrence following radiotherapy occurs in many cancer patients. A key to solving this problem is the optimization of radiosensitivity. In recent years, long non-coding RNAs (lncRNAs), which affect the occurrence and development of tumors through a variety of mechanisms, have become a popular research topic. LncRNAs have been found to influence radiosensitivity by regulating various mechanisms, including DNA damage repair, cell cycle arrest, apoptosis, cancer stem cells regulation, epithelial-mesenchymal transition, and autophagy. LncRNAs are expected to become a potential therapeutic target for radiotherapy in the future. This article reviews recent advances in the role and mechanism of lncRNAs in tumor radiosensitivity.

Source: Bioscience Reports

DOI: 10.1042/bsr20190590

Authors: Jiamin Zhu, Shusen Chen, Baixia Yang, Weidong Mao, Xi Yang, Jing Cai