Synthesis and Сytotoxicity of A-Azepanobetulinic Acid N -Methyl-Piperazinylamide
Year: 2019
Type: article
Abstract: The synthesis of A-azepanobetulinic acid N-methylpiperazinylamide was performed through a series of transformations (oximation, Beckmann rearrangement, reduction) of previously synthesized betulonic acid N-methylpiperazinylamide. In vitro cytotoxic activity was detected for the obtained compound against a number of cancer cell lines, and its potential was revealed as an antibacterial agent.
Source: Natural Product Communications
Institutions: Ufa Institute of Chemistry, Lomonosov Moscow State University, National Research University Higher School of Economics, Skolkovo Institute of Science and Technology, National University of Science and Technology, D. Mendeleyev University of Chemical Technology of Russia, Russian Academy of Sciences, Moscow Institute of Physics and Technology, Institute of Biochemistry and Genetics of Ufa Scientific Centre
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $2,650
Funder: Russian Science Foundation
OpenAlex ID: W2966433950