Work

Herpes Simplex Virus 1 MicroRNA miR-H28 Exported to Uninfected Cells in Exosomes Restricts Cell-to-Cell Virus Spread by Inducing Gamma Interferon mRNA

Year: 2019

Type: article

Abstract: In this report, we show that IFN-γ is produced by HSV-1 viral miR-H28 and viral replication is blocked in cells exposed to IFN-γ before infection but not during or after infection. The inevitable conclusion is that HSV-1 induces IFN-γ to curtail its spread from infected cells to uninfected cells. In essence, this report supports the hypothesis that HSV-1 encodes functions that restrict the transmission of virus from cell to cell.

Source: Journal of Virology

DOI: 10.1128/jvi.01005-19

Authors: Rongquan Huang, Jiaming Wu, Xusha Zhou, Haifang Jiang, Grace Guoying Zhou, Bernard Roizman

Institutions: State Key Laboratory of Respiratory Disease, Guangzhou Medical University, University of Chicago

Language: English

Topic: Herpesvirus Infections and Treatments

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Natural Science Foundation of Guangdong Province, Science, Technology and Innovation Commission of Shenzhen Municipality