Preeclampsia: Maternal Systemic Vascular Disorder Caused by Generalized Endothelial Dysfunction Due to Placental Antiangiogenic Factors
Year: 2019
Type: review
Abstract: Preeclampsia, a systemic vascular disorder characterized by new-onset hypertension and proteinuria after 20 weeks of gestation, is the leading cause of maternal and perinatal morbidity and mortality. Maternal endothelial dysfunction caused by placental factors has long been accepted with respect to the pathophysiology of preeclampsia. Over the past decade, increased production of placental antiangiogenic factors has been identified as a placental factor leading to maternal endothelial dysfunction and systemic vascular dysfunction. This review summarizes the recent advances in understanding the molecular mechanisms of endothelial dysfunction caused by placental antiangiogenic factors, and the novel clinical strategies based on these discoveries.
DOI: 10.3390/ijms20174246
Institutions: The University of Osaka, The University of Tokyo
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,824
Awards: Development of a novel method for Induction of Fetal Immunological Tolerance using Maternal microchymerism, Basic study for preeclampsia therapeutics by phosphodiesterase-5 inhibitor, Elucidation of pathophysiology and development of new therapeutic agents for preeclampsia through complement inhibition
OpenAlex ID: W2970423612