Work

Mitochondrial Antioxidant Enzymes and Endurance Exercise-induced Cardioprotection against Ischemia-Reperfusion Injury

Year: 2018

Type: article

Abstract: Coronary artery disease (CAD) is the most common cause of myocardial injuries induced by prolonged cessation of blood flow (ischemia) to cardiac myocytes due to atherosclerosis. For several decades, many clinical trials have been applied to protect hearts against ischemia and reperfusion (I/R) injuries, but failed to show significant improvement in the restoration of cardiac function. By contrast, growing evidence has shown that a non-pharmacological strategy, endurance exercise, provides cardioprotection against ischemic myocardial injuries. Despite the prominent cardioprotective benefit; however, the exact molecular and cellular protective mechanisms remain an exciting issue. Nonetheless, given that excess production of reactive oxygen species (ROS) is a primary mediator of cardiac injuries caused by an I/R insult, improved myocardial antioxidant capacity in response to endurance exercise has been suggested to be a key mechanism against I/R injuries, in particular, Therefore, this review will focus the role of endurance exercise-induced improvement in myocardial antioxidants in cardioprotection against I/R induced myocardial infarction.

Source: Sports and Exercise Medicine - Open Journal

DOI: 10.17140/semoj-4-155

Authors: Insu Kwon, Yongchul Jang, Wankeun Song, Mark H. Roltsch, Youngil Lee

Institution: University of West Florida

Language: English

Topic: Cardiac Ischemia and Reperfusion

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: University of West Florida