Ommaya reservoir for intraventricular chemotherapy of children with neuro-oncological and oncohematological diseases: Design history, implantation technology, and experience gained at the Federal Research Center of Pediatric Hematology, Oncology, and Immunology named after Dmitry Rogachev
Year: 2015
Type: article
Study design: Observational Study
Abstract: Ommaya reservoir is a convenient and reliable port for intraventricular injection of chemotherapeutic drugs in patients with oncohematological and neuro-oncological diseases. A total of 45 Ommaya reservoirs were implanted in 45 patients at the Federal Research Center of Pediatric Hematology, Oncology, and Immunology named after Dmitry Rogachev (Moscow) in 2012-2015. Because of small ventricles in most cases Ommaya reservoirs were implanted by stereotactic procedure. Intraventricular injection of methotrexate supported a high and stable concentration of the drug in the cerebrospinal fluid and proved to be a good alternative to intrathecal administration. In hydrocephalus Ommaya reservoir could be combined with pressure-regulated ventriculoperitoneal shunt, this providing a high concentration of methotrexate in the cerebrospinal fluid, safe for the patient.
Authors: S. S. Ozerov, A. V. Melnikov, A. E. Samarin, G. V. Tereshchenko, E. V. Kumirova, N. V. Myakova, N. S. Grachev, O. G. Zheludkova
Language: English
Subfield: Clinical Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W2974196845