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Adult influenza A (H3N2) with reduced susceptibility to baloxavir or peramivir cured after switching anti-influenza agents

Year: 2019

Type: article

Abstract: We describe two adults with A/H3N2 influenza with (patient 1), and without (patient 2) polymerase acidic (PA) subunit I38 T substitution during the same season. Patient 1 had a reduced clinical response to baloxavir, a cap-dependent endonuclease inhibitor (CEI), but was cured by peramivir, a neuraminidase inhibitor. Baloxavir was clinically effective for patient 2, for whom peramivir had been ineffective. Susceptibility to baloxavir can be decreased by a PA unit mutation, but response to treatment can be increased by switching and/or combination with a neuraminidase inhibitor, even though CEI are clinically effective against influenza in adults.

Source: IDCases

DOI: 10.1016/j.idcr.2019.e00650

Authors: Masafumi Seki, Yuko Sakai-Tagawa, Atsuhiro Yasuhara, Yuji Watanabe

Institutions: Tohoku Medical and Pharmaceutical University Hospital, Tohoku Medical and Pharmaceutical University, Institute of Medical Science, The University of Tokyo, The University of Tokyo

Language: English

Topic: Influenza Virus Research Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $550