Inflammatory Myofibroblastic Tumor After Lung Transplant—A Rare and Aggressive Complication: A Case Report
Year: 2019
Type: article
Study design: Case Report
Abstract: INTRODUCTION: Malignant diseases are well-known complications after lung transplantation (LT). Among these, inflammatory myofibroblastic tumor (IMT) is a rare neoplasm with a not well-known and often aggressive biological behavior. MATERIAL AND METHODS: We hereby describe 2 cases of cystic fibrosis patients who underwent bilateral sequential LT (BSLT) complicated by IMT. RESULTS: A 26-year-old man presented a right endobronchial lesion 6 months after BSLT. Two consecutive fiber bronchoscopic biopsies showed granulation tissue. For the persistent lesion growth, the patient underwent a transthoracic biopsy showing histologic diagnosis of IMT. Therefore, he underwent to right pneumonectomy that was unfortunately complicated after 6 months with a late bronchopleural fistula and empyema with exitus 6 months later. A 31-year-old woman 1 year after BSLT presented with a left voluminous pleural-parenchymal lesion; the histologic examination after biopsy revealed an IMT. She underwent a removal of the lesion with a macroscopic R0 resection. Histologic, immunophenotypic, and cytogenetic examinations showed a strong overexpression of anaplastic lymphoma kinase requiring biological adjuvant therapies; however, the patient refused it. Four years later, she presented a recurrence treated with debulking procedure and adjuvant radiotherapy. At last follow-up, the patient was alive with stable disease and optimal graft function. CONCLUSIONS: Although IMT is a rare complication after lung transplant, to obtain a careful diagnosis, an early and aggressive treatment is mandatory.
Source: Transplantation Proceedings
Authors: Camilla Poggi, Ylenia Pecoraro, Carolina Carillo, Marco Anile, Davide Amore, Sara Mantovani, Giuseppe Naldi, Andreina Pagini, Massimiliano Bassi, Sara Cagnetti, Emilia Mottola, Federica D’Agostino, Jacopo Vannucci, Angelina Pernazza, Giuseppe Cimino, Daniela Savi, Sara Gomellini, Francesco Pugliese, Tiziano De Giacomo, Erino Angelo Rendina, Federico Venuta, Daniele Diso
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $2,500
OpenAlex ID: W2979377643