Epidemiologic Trends of Diarrhea-causing Virus Infection Analyzed by Multiplex Reverse Transcription PCR in Cheonan, Korea, 2010-2018
Year: 2019
Type: article
Study design: Observational Study
Abstract: Gastroenteritis with diarrhea is one of the most infectious diseases in the world following respiratory infections.Notably, diarrhea-causing viruses (DVs) cause more than 70% of such cases.In this study, 3,065 stool specimens from patients with diarrhea (median age, 1.1 years; range, 0.0-91.1 years), who were admitted to the DanKook University Hospital, were examined using multiplex reverse transcription PCR (mRT-PCR).The target viruses were astrovirus (AstV), enteric adenovirus (EAdV), group A rotavirus (RotV), norovirus GI (NoV-GI), and norovirus GII (NoV-GII).The mRT-PCR results were analyzed based on various factors such as seasonality, age, presence of co-infection, and analyzed trends.The detection rate of the DVs during the study period was found to be 30.8%(n = 943/3,065).When the detection rate was analyzed monthly, the DV detection rate was found to be highest between December to January.Of the detected DVs, NoV-GII was the most common, accounting for 45.5% of the detected viruses (n = 446/980).Notably, 86.5% (n = 848/980) of the pathogens were detected in individuals who were less than 5 years of age.During the study period, NoV-GII and RotV showed alternating trends.In addition, both the number and rate of co-infections increased.
Authors: Ji On Park, Jae-Sik Jeon, Jae Kyung Kim
Institution: Dankook University
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2979508201