Year: 2019
Type: article
Abstract: Arbovirus infections in Brazil, including yellow fever, dengue, zika, and chikungunya, result in considerable morbidity and mortality and are pressing public health concerns. However, our understanding of these outbreaks is hampered by the limited availability of genomic data. In this study, we investigated the genetic diversity and spatial distribution of YFV during the current outbreak by analyzing genomic data from areas in southeastern Brazil not covered by other previous studies. To gain insights into the routes of YFV introduction and dispersion, we tracked the virus by sequencing YFV genomes sampled from nonhuman primates and infected patients from the southeastern region. Our study provides an understanding of how YFV initiates transmission in new Brazilian regions and illustrates that genomics in the field can augment traditional approaches to infectious disease surveillance and control.
Source: Journal of Virology
DOI: 10.1128/jvi.01623-19
Authors: Marta Giovanetti, Marcos Cesar Lima de Mendonça, Vagner Fonseca, Maria Angélica Mares-Guia, Allison Fabri, Joilson Xavier, Jaqueline Goes de Jesus, Tiago Gräf, Cintia Damasceno dos Santos Rodrigues, Carolina Cardoso dos Santos, Simone Alves Sampaio, Flavia Lowen Levy Chalhoub, Fernanda de Bruycker Nogueira, Julien Theze, Alessandro Pecego Martins Romano, Daniel Garkauskas Ramos, Andre Luiz de Abreu, Wanderson Kleber Oliveira, Rodrigo Fabiano do Carmo Said, Carlos F. Campelo de Alburque, Tulio de Oliveira, Carlos Augusto Fernandes, Shirlei Ferreira Aguiar, Alexandre Chieppe, Patrícia Carvalho Sequeira, Nuno Rodrigues Faria, Rivaldo Venâncio Cunha, Luiz Carlos Junior Alcantara, Ana Maria Bispo de Filippis
Institutions: Universidade Federal de Minas Gerais, Instituto Oswaldo Cruz, University of Cambridge, University of KwaZulu-Natal, Ministério da Saúde, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, University of Oxford, Pan American Health Organization (Brasil), Universidade Federal de Mato Grosso do Sul, Instituto de Tecnologia em Imunobiológicos
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2980239290