PM2.5 exposure and oxidative stress in a cohort of obese with and without asthma
Year: 2019
Type: conference-abstract
Abstract: TPS 684: Long-term health effects of air pollutants 1, Exhibition Hall, Ground floor, August 26, 2019, 3:00 PM - 4:30 PM Background. In Latin American more than 100 million people are exposed to air pollutants which, frequently are above WHO standards. Oxidative stress and airway inflammation are effects related to particulate matter (PM2.5) exposure. Objective: To evaluate PM2.5 concentrations and its association with oxidative stress and airway inflammation biomarkers in adolescents from Mexico. Methods: A longitudinal study was conducted in asthmatic and non-asthmatic adolescents with overweight and obesity along 2008 to 2011. PM2.5 concentrations were obtained from the Mexican air quality monitoring network and georeferencing. The 8-isoprostane, Glutathione (GSH), Oxidised glutathione (GSSG), nitrates, nitrites and nitric oxide (FeNO) were determined in exhaled vapor condensed. Statistical analyses of mixed models for longitudinal data, multiple regression models and interaction analysis between pollutants and biomarkers were performed. Results. In the airway inflammation was observed a significant increase for each unit change in the PM2.5 in the nonasthmatic children, in contrast with asthmatic, it was a decrement. For the asthmatic group each increase of 10 µg / m3 in PM2.5 was related to a 5.09 times of increase in Ln(FeNO) based on its predicted value, and the increment for non-asthmatic was of 4%. For the exhaled nitric oxide, an interaction between PM2.5 and the asthmatic state (p = 0.008) was observed. For nitrates and nitrates as well as in the 8-isoprostane, resulting in a PM2.5 positive effect on biomarkers: 0.11 logarithmic units (95 % CI: 0.02, 0.20) and 1.92 pg / mL (95 % CI: 0.59, 3.24), respectively. In the case of GSH, the effect on asthmatics was 22.03 points for each increase of 10 µg / m3 in PM2.5 and 0.48 points for the non-asthmatic group. Conclusion: Our results demonstrate that PM2.5 exposure increase inflammation and oxidative stress in obease non-asthmatic achieving levels similar to the asthmatic adolescents.
Source: Environmental Epidemiology
Institution: Instituto Nacional de Salud Pública
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,200
OpenAlex ID: W2981892439