Work

Biology of IL-36 Signaling and Its Role in Systemic Inflammatory Diseases

Year: 2019

Type: review

Abstract: Interleukin (IL)-36 is a member of the IL-1 superfamily and includes three agonists (IL-36α, IL-36β, and IL-36γ) and an antagonist (IL-36Ra). IL-36 agonists bind to heterodimeric receptor complexes. Then, the heterotrimer complexes signal via intracellular functional domains, binding to downstream signaling proteins and inducing inflammatory responses. In this review, we summarized the current knowledge about the biological role of IL-36 and its correlation with systemic inflammatory diseases. The information collected will help to increase the understanding of the potential of IL-36 and may give clues for developing novel therapeutic strategies.

Source: Frontiers in Immunology

DOI: 10.3389/fimmu.2019.02532

Authors: Zhi-Chao Yuan, Wang-Dong Xu, Xiao-Yan Liu, Xing-You Liu, An-Fang Huang, Lin-Chong Su

Institutions: Southwest Medical University, Affiliated Hospital of Southwest Medical University, Minda Hospital

Language: English

Topic: Cytokine Signaling Pathways and Interactions

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,950