Rumex crispus Extract Exerts Anti-Diabetic Properties in Streptozotocin-Induced Diabetes in Rats
Year: 2019
Type: article
Abstract: Rumex crispus is a natural, wild plant that grows spontaneously on riverside and wet meadows, and has been used for centuries in alternative medicine. In the present study, the effects of R. crispus on body weights, fasting blood glucose levels, plasma lipid profile, liver enzyme activities and antioxidant system were investigated in streptozotocin (STZ) induced diabetic rats. The animals were divided into 4 groups. Group I: control; group II: 3 mg kg-1 R. crispus; group III: 50 mg kg-1 Streptozotocin (STZ)-induced diabetes; group IV: 50 mg kg-1 STZ-induced diabetes + 3 mg kg-1 R.crispus. It was found that R. crispus extract reduced diabetes-related weight loss and blood glucose levels 10 days after the formation of diabetes. At the end of 14-day treatment period, HDL cholesterol (HDL-C) levels significantly decreased (P<0.01) while triglyceride, LDL cholesterol (LDL-C) and VLDL cholesterol (VLDL-C) levels increased in R. crispus supplemented diabetic rats (P<0.001). The levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were significantly increased in response to R. crispus (P <0.001). Total antioxidant status (TAS) significantly decreased and total oxidant status (TOS) increased in diabetic group; however, in response to R. crispus treatment, TAS significantly increased and TOS decreased relative to control group (P<0.001, for both). Supplementation of R. crispus extract shows anti-diabetic properties in rats and might have a clinical potential for diabetic individuals.
DOI: 10.21597/jist.585885
Authors: Özgen ÇELİK, Evren KOÇ
Institution: Kafkas University
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2988427770