Year: 2019
Type: article
Abstract: Pyroptosis is an inflammatory form of cell death triggered by certain inflammasomes, leading to the cleavage of gasdermin D (GSDMD) and activation of inactive cytokines like IL-18 and IL-1β. Pyroptosis has been reported to be closely associated to some diseases like atherosclerosis and diabetic nephropathy. Recently, some studies found that pyroptosis can influence the proliferation, invasion and metastasis of tumor, which regulated by some non-coding RNAs and other molecules. Hence, we provided an overview of morphological and molecular characteristics of pyroptosis. We also focus on mechanism of regulating pyroptosis in tumor cells as well as the potential roles of pyroptosis in cancer to explore potential diagnostic markers in cancers contributing to the prevention and treatment in cancers.
Source: Biomedicine & Pharmacotherapy
Authors: Yuan Fang, Shengwang Tian, Yutian Pan, Wei Li, Qiming Wang, Yu Tang, Tao Yu, Xi Wu, Yongkang Shi, Pei Ma, Yongqian Shu
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,000
Funders: National Natural Science Foundation of China, Nanjing Medical University, Priority Academic Program Development of Jiangsu Higher Education Institutions, National Key Research and Development Program of China, National Key Research and Development Program of China Stem Cell and Translational Research
OpenAlex ID: W2989083977