Work

Solubilization of Bifonazole in the Presence of Carboxymethylated-β- Cyclodextrin

Year: 2019

Type: conference-paper

Abstract: Recently, many technological methods of enhancing the solubility and dissolution characteristics of poorly water soluble drugs have been reported in the literature. Сyclodextrins are able to form watersoluble non-covalent inclusion complexes with many poorly soluble lipophilic drugs. The purpose of this study is to evaluate the possibility of interaction of the antifungal drug Bifonazole (BFZ) through complexation with carboxymethylated-β-cyclodextrin (КМ-β-CD). Based on the data obtained, we canconclude that the presence of KM-β-CD improves solubilization of BFZ more than 50 times.Кеуwords: cyclodextrins, solubility, poorly-water soluble drugs, bifonazole

Source: Chemical technology and engineering. Proceedings

DOI: 10.23939/cte2019.01.198

Authors: Sеrgii Riabov, Larisa Kobrina, Sеrgii Sinelnikov, Daria Bandurina, Oleg Moskalenko

Institutions: National Academy of Sciences of Ukraine, Institute of Macromolecular Chemistry, Nizhyn Gogol State University

Language: English

Topic: Drug Solubulity and Delivery Systems

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W2989453035