[Quality of life, in depressed patients in Primary Health Care setting. Effectiveness and safety of venlafaxine extended release].
Year: 2003
Type: article
Abstract: INTRODUCTION: The aim of this observational study was to evaluate effectiveness, tolerability and impact on quality of life of treatment with venlafaxine extended release at a dose of 75 to 150 mg/day, in depressed outpatients treated in Primary Health Care. METHODS: Observational, prospective, open-labeled study, carried out by 882 Primary Health Care physicians. Outpatients, between 18 and 70 years of age with depressive symptomatology susceptible of treatment, with a Hamilton Depression Scale (HAM-D17) score 14 were included. Daily doses of 75 or 150 mg of venlafaxine extended release were administered orally for 24 weeks. Antidepressant effectiveness was assessed using the HAM-D17 scale and quality of life with the Quality of Life in Depression Scale (QLDS), Spanish version. RESULTS: 4,747 patients were recruited, of which 4,320 were included in a intention to treat effectiveness analysis and 4,557 patients in a safety analysis. HAM-D17 and QLDS mean score significantly decreased from week 4 to the end of study. 86,2% of the patients were responders and 73.8% achieved remission of the symptoms. Likewise, 95% reported absence or mild somatic and psychic anxiety on the final visit. Tolerability was considered good or excellent for 98.7% subjects. 191 patients (4.2%) reported adverse events. CONCLUSIONS: Venlafaxine extended release is a safe and effective drug that reduces depressive symptoms of Primary Health Care patients and improves their quality of life.
Source: Actas Españolas de Psiquiatría
Authors: E Baca Baldomero, S Cervera Enguix
Institution: Hospital Universitario Puerta de Hierro Majadahonda
Language: Spanish
Subfield: Pharmacology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2990172087