A new and efficient synthesis of unsaturated benzoxazepines using sodium metabisulfite and potassium permanganate as oxidative reagents
Year: 2019
Type: article
Abstract: A mild oxidation of 1,2,3,5,6,11b-hexahydroimidazo[1,2-d][1,4]benzoxazepines using KMnO 4 in DMF at room temperature produces a mixture of unsaturated and partially unsaturated [1,4]benzoxazepines in very good yields.Condensation of 2-(2-bromoethoxy)benzaldehydes with either o-phenylenediamine or ethylenediamine in the presence of oxidative reagents such as sodium metabisulfite in acetonitrile at reflux temperature produces a series of [1,4]benzoxazepines, in a simple way and in good yields.Structures of all the synthesized compounds were established in detail via NMR, HRMS spectra and single-crystal X-ray diffraction analyses.
Source: ARKIVOC
Authors: Muhammad Ashram, Firas F. Awwadi
Institutions: Mutah University, University of Jordan
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
Funder: University of Jordan
OpenAlex ID: W2990318207