Year: 2019
Type: article
Abstract: circASXL1-1 regulates BAP1 deubiquitinase activity in leukemiaMutations in epigenetics remodelers such as ASXL1 (additional sex combs 1) have been identified in acute myeloid leukemia, chronic myelomonocytic leukemia and myelodysplastic syndrome and are associated with poor overall survival. 1Some ASXL1 mutations resulting in a loss of protein expression have been shown to contribute to myeloid transformation through loss of H3K27me3 expression at the HOX gene loci. 2 On the other hand, some ASXL1 mutations result in the expression of a truncated protein, which can bind and activate BRCA-1 associated protein 1 (BAP1), a deubiquitinase enzyme, to form the polycomb repressive deubiquitinase complex (PR-DUB).4][5] Conversely, reduced BAP1 activity is sufficient to halt the leukemogenesis driven by truncated ASXL1 protein, 6 highlighting the importance of a balanced ASXL1-BAP1 axis in normal hematopoiesis.
Source: Haematologica
Institutions: National University of Singapore, Cancer Science Institute of Singapore, Agency for Science, Technology and Research, Singapore Institute for Clinical Sciences, National University Health System, National University Cancer Institute, Singapore, Nanyang Technological University, Institute of Molecular and Cell Biology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, Harvard University, Harvard Stem Cell Institute
Language: English
Topic: Circular RNAs in diseases
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,157
Funders: National Research Foundation, National University of Singapore, Singapore Institute for Clinical Sciences, National Research Foundation Singapore, Ministry of Education, India, National University Cancer Institute, Singapore, National Institutes of Health, Directorate for Biological Sciences, Harvard Stem Cell Institute, Medical Research Council, National Medical Research Council, Institute of Molecular and Cell Biology, Cancer Science Institute of Singapore, National University of Singapore, National Heart, Lung, and Blood Institute, National Cancer Institute
OpenAlex ID: W2990946906