Work

Gentamycin elution from polymethylmethacrylate and bone graft substitute: Comparison between commercially available and home-made preparations

Year: 2019

Type: article

Abstract: Polymethylmethacrylate (PMMA) represents the current gold standard as an antibiotic delivery carrier in orthopaedic surgery. Despite the accepted use of local antibiotic carriers, there aren't any conclusive data comparing PMMA to Bone Graft Substitutes. The aim of this in vitro study was to compare the elution profile of gentamicin from various preparations of PMMA cements and Herafill beads. All cements had high initial elution during the first hour which then slowly decreased, Herafill beads on the other hand showed its higher elution around the eighth hour. Herafill, in general, presented the highest elution of gentamicin regardless of its input amount.

Source: Journal of Orthopaedics

DOI: 10.1016/j.jor.2019.11.034

Authors: Makrina Karaglani, Evmorfia Tzitzikou, Stylianos Tottas, Ioannis Kougioumtzis, Konstantinos Arvanitidis, George Kolios, Ekaterini Chatzaki, Georgios I. Drosos

Institutions: Democritus University of Thrace, University Hospital of Alexandroupolis

Language: English

Topic: Orthopedic Infections and Treatments

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2990966948

FWCI: 1.173

Cites: 15

Cited by: 10

Related to: 10