Work

Nimodipine-Loaded Pluronic® Block Copolymer Micelles: Preparation, Characterization, In-vitro and In-vivo Studies.

Year: 2016

Type: article

Abstract: release of NM from polymeric micelles presented the sustained-release profile. Animal studies revealed the existence of fluorescein 5-isothiocyanate-labeled micelles in rat CSF following intraperitoneal administration, proving that the micelles crossed the BBB. Anticonvulsant effect of NM was shown to be significantly greater than that of NM solution. Our results confirmed that Pluronic micelles might serve as a potential nanocarrier to improve the activity of NM in brain.

Source: PubMed Central

Authors: Farzaneh Sotoudegan, Mohsen Amini, Mehrdad Faizi, Reza Aboofazeli

Institutions: Shahid Beheshti University, Shahid Beheshti University of Medical Sciences, Tehran University of Medical Sciences

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Shahid Beheshti University of Medical Sciences

OpenAlex ID: W2992900599

FWCI: 0.582

Cites: 67

Cited by: 36

Related to: 10