The Antibacterial Activities of Durian Rinds Extract (Durio Zibethinus) Against Propionibacterium acne
Year: 2019
Type: conference-paper
Abstract: Acne vulgaris is a kind of skin diseases which caused by Propionibacterium acne bacterias. Nowadays, the treatments of acne are still using the antibiotics as a first protocol, but the overuses of this in a long duration can be resistants. Therefore, it is very important to find some candidates of natural products to become antibacterial agents in the acne treatments. One of the natural products is Durian (Durio zibethinus (Linn)), a part of durian which is called rinds of durian known as mesocarpium, it contains a lot of organic chemical compounds, there are alkaloids, saponins, flavonoids, tannins, and phenolics which have antibacterial activities especially in flavonoids. This study was aimed to determine the antibacterial activity of durian rinds extracts to the Propionibacterium acnes bacterias. This study was used as a randomized completed trial design. The test of antibacterial activities uses the dilution method in 96 well plate and diffusion method, then the amount of the colony was measured by colony counter. The treatments were using a series concentrations 2.5%, 5%, 7.5%, and 10%, the negative control using 10% of DMSO and the positive control using clindamycine. The Results showed that the rinds of durian have given the moderates antibacterial activities at the 7.5% concentrations with the MIC value of 5% and the colony number was 67 colonies. Based on this results, it might conclude that the rinds of durian have the potential as an antibacterial agent which was bacteriostatic.
Authors: F Fitrianingsih, A Soyata, S Wigati
Institution: Universitas Jambi
Language: English
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2994709342