Work

Assessment of Clofazimine and TB47 Combination Activity against Mycobacterium abscessus Using a Bioluminescent Approach

Year: 2019

Type: article

Abstract: Mycobacterium abscessus is intrinsically resistant to most antimicrobial agents. The emerging infections caused by M. abscessus and the lack of effective treatment call for rapid attention. Here, we intended to construct a selectable marker-free autoluminescent M. abscessus strain (designated UAlMab) as a real-time reporter strain to facilitate the discovery of effective drugs and regimens for treating M. abscessus . The UAlMab strain was constructed using the dif /Xer recombinase system.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.01881-19

Authors: Yang Liu, Yaoju Tan, M. Mahmudul Islam, Yuanyuan Cao, Xiaoyun Lu, Sheng Zeng, H. M. Adnan Hameed, Peipei Zhou, Xingshan Cai, Shuai Wang, Julius N. Mugweru, Guoliang Zhang, Huancai Yin, Jianxiong Liu, Eric Nuermberger, Tianyu Zhang

Institutions: Chinese Academy of Sciences, Guangzhou Institutes of Biomedicine and Health, State Key Laboratory of Respiratory Disease, Guangzhou Chest Hospital, University of Chinese Academy of Sciences, Jinan University, University of Embu, Southern University of Science and Technology, Shenzhen Third People’s Hospital, Suzhou Institute of Biomedical Engineering and Technology, Johns Hopkins University

Language: English

Topic: Mycobacterium research and diagnosis

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Natural Science Foundation of China, National Institute of Allergy and Infectious Diseases

Awards: Exploiting a robust drug discovery portfolio to develop effective regimens to treat Mycobacterium abscessus lung infection, G8137512843, G897348419

OpenAlex ID: W2994743409

FWCI: 2.474

Cites: 37

Cited by: 25

Related to: 10