Adenosquamous carcinoma may have an inferior prognosis to signet ring cell carcinoma in patients with stages I and II gastric cancer
Year: 2019
Type: article
Study design: Observational Study
Abstract: BACKGROUNDPrimary gastric adenosquamous carcinoma (ASC) is an exceedingly rare histological subtype.Gastric signet ring cell carcinoma (SRC) is a unique subtype with distinct tumor biology and clinical features.The prognosis of gastric ASC vs SRC has not been well established to date.We hypothesized that further knowledge about these distinct cancers would improve the clinical management of such patients. AIMTo investigate the clinicopathological characteristics and prognosis of gastric ASC vs SRC. METHODSA cohort of gastric cancer patients was retrospectively collected from the Surveillance, epidemiology, and end results program database.The 1:4 propensity score matching was performed among this cohort.The clinicopathological features and prognosis of gastric ASC were compared with gastric SRC by descriptive statistics.Kaplan-Meier method was utilized to calculate the median survival of the two groups of patients.Cox proportional hazard regression models were used to identify prognostic factors. RESULTSTotally 6063 patients with gastric ASC or SRC were identified.A cohort of 465 patients was recruited to the matched population, including 370 patients with SRC and 95 patients with ASC.Gastric ASC showed an inferior prognosis to SRC after propensity score matching.In the post-matching cohort, the median cancer specific survival was 13.0 (9.7-16.3)mo in the ASC group vs 20.0 (15.7-24.3)mo in the SRC group, and the median overall survival had a similar trend (P < 0.05).ASC and higher tumor-node-metastasis stage were independently associated WJGO https://www.wjgnet.com
Authors: Yu-Xin Chu, Hong-Yun Gong, Qin-Yong Hu, Qi-Bin Song
Institution: Renmin Hospital of Wuhan University
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W2995507410