Work

Polysaccharides in Ocular Drug Delivery

Year: 2019

Type: review

Abstract: Polysaccharides, such as cellulose, hyaluronic acid, alginic acid, and chitosan, as well as polysaccharide derivatives, have been successfully used to augment drug delivery in the treatment of ocular pathologies. The properties of polysaccharides can be extensively modified to optimize ocular drug formulations and to obtain biocompatible and biodegradable drugs with improved bioavailability and tailored pharmacological effects. This review discusses the available polysaccharide choices for overcoming the difficulties associated with ocular drug delivery, and it explores the reasons for the dependence between the physicochemical properties of polysaccharide-based drug carriers and their efficiency in different formulations and applications. Polysaccharides will continue to be of great interest to researchers endeavoring to develop ophthalmic drugs with improved effectiveness and safety.

Source: Pharmaceutics

DOI: 10.3390/pharmaceutics12010022

Authors: Natallia Dubashynskaya, Daria Poshina, Sergei Raik, Arto Urtti, Yury A. Skorik

Institutions: Institute of Macromolecular Compounds, St Petersburg University, University of Helsinki, University of Eastern Finland

Language: English

Topic: Advanced Drug Delivery Systems

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,621