Imbalance of GutStreptococcus,Clostridium, andAkkermansiaDetermines the Natural Course of Atopic Dermatitis in Infant
Year: 2020
Type: article
Abstract: PURPOSE: The roles of gut microbiota on the natural course of atopic dermatitis (AD) are not yet fully understood. We investigated whether the composition and function of gut microbiota and short-chain fatty acids (SCFAs) at 6 months of age could affect the natural course of AD up to 24 months in early childhood. METHODS: Fecal samples from 132 infants were analyzed using pyrosequencing, including 84 healthy controls, 22 transient AD and 26 persistent AD subjects from the Cohort for Childhood Origin of Asthma and Allergic Diseases (COCOA) birth cohort. The functional profile of the gut microbiome was analyzed by whole-metagenome sequencing. SCFAs were measured using gas chromatography-mass spectrometry. RESULTS: negatively correlated with SCORAD score. The persistent AD group showed decreased gut microbial functional genes related to oxidative phosphorylation compared with healthy controls. Butyrate and valerate levels were lower in transient AD infants compared with healthy and persistent AD infants. CONCLUSIONS: Compositions, functions and metabolites of the early gut microbiome are related to natural courses of AD in infants.
Institutions: Asan Medical Center, University of Ulsan, Hallym University, Pusan National University Yangsan Hospital, Catholic Kwandong University International St. Mary's Hospital, Catholic Kwandong University, Chonnam National University, Chonnam National University Hospital, Hallym University Sacred Heart Hospital, Dankook University Hospital, Inje University Sanggye Paik Hospital, Seoul National University, CHA University, CHA University Gangnam Medical Center, Yonsei University, Yonsei University Health System, Samsung Medical Center, Sungkyunkwan University
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W2997315136