Sungeidinesfrom a Non-canonical Enediyne BiosyntheticPathway
Year: 2020
Type: paratext
Abstract: Wereport the genome-guided discovery of sungeidines, a class of
microbial secondary metabolites with unique structural features. Despite
evolutionary relationships with dynemicin-type enediynes, the sungeidines
are produced by a biosynthetic gene cluster (BGC) that exhibits distinct
differences from known enediyne BGCs. Our studies suggest that the
sungeidines are assembled from two octaketide chains that are processed
differently than those of the dynemicin-type enediynes. The biosynthesis
also involves a unique activating sulfotransferase that promotes a
dehydration reaction. The loss of genes, including a putative epoxidase
gene, is likely to be the main cause of the divergence of the sungeidine
pathway from other canonical enediyne pathways. The findings disclose
the surprising evolvability of enediyne pathways and set the stage
for characterizing the intriguing enzymatic steps in sungeidine biosynthesis.
Source: Figshare
Language: English
Subfield: Applied Microbiology and Biotechnology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2998958799