Work

Activation of Leukopoiesis in Rat Blood with Trimecaine‐Based Ionic Compounds

Year: 2020

Type: article

Abstract: A study of myelostimulating activity of ionic compounds-trimecaine alkyl iodide derivatives under the cipher BIV (BIV-117, BIV-118, and BIV-119) was conducted on a model of doxorubicin pancytopenia in white laboratory rats. It was established that the compounds BIV-117 and BIV-119 had a pronounced leukopoiesis-stimulating activity, exceeding the activity of the methyluracil as a comparison drug. Compounds BIV-117 and BIV-119 had erythropoiesis- and thrombocytopoiesis-stimulating activity at the level of methyluracil.

Source: BioMed Research International

DOI: 10.1155/2020/7636290

Authors: Lyailya Baktybayeva, Valentina Yu, Alexey Zazybin, Darya Zolotareva, Anuar Dauletbakov

Institutions: Al-Farabi Kazakh National University, Kazakh-British Technical University, National Academy of Sciences of the Republic of Kazakhstan, Satbayev University

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,680