Work

Multispecific Antibodies: DNA‐Mediated Assembly of Multispecific Antibodies for T Cell Engaging and Tumor Killing (Adv. Sci. 2/2020)

Year: 2020

Type: article

Abstract: Nucleic acid–mediated protein–protein assembly (NAPPA) represents a true modular means for preparing multispecific antibodies (MsAbs). In article number 1900973, James J. Chou and co-workers prepare MsAbs displaying T-cell engaging and tumor killing properties in vivo. NAPPA allows for the preparation of individual antibody modules separately, stored in an antibody library (middle cubic grid), which can be used to assemble a large variety of MsAbs immediately before use.

Source: Advanced Science

DOI: 10.1002/advs.202070010

Authors: Liqiang Pan, Chan Cao, Changqing Run, Liujuan Zhou, James J. Chou

Institutions: Zhejiang University, Harvard University

Language: English

Topic: Monoclonal and Polyclonal Antibodies Research

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $5,000

OpenAlex ID: W3000752667

FWCI:

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