Work

Transcriptomic analysis reveals that IL-1R8/Sigirr is a novel macrophage migration regulator and suppresses macrophage proliferation through p38 MAPK signaling pathway

Year: 2020

Type: article

Abstract: IL-1R8, also known as the Single immunoglobin interleukin-1 (IL-1)-related receptor (Sigirr), has been demonstrated as a negative regulator of IL-1R and Toll-like receptor (TLR) downstream signaling pathways and inflammation. However, the role of IL-1R8 in macrophage migration and proliferation remains unknown. Here we investigated transcriptome proﬁles of WT and Il1r8-deficient splenocytes and found that innate immunity and cell migration related pathways were signiﬁcantly correlated with IL-1R8 expression. Cell migration-related genes were downregulated in Il1r8−/− splenocytes or IL-1R8-depleted RAW264.7 cells. Further experiments revealed that IL-1R8-depleted RAW264.7 cells or Il1r8−/− BMDMs exhibited impaired cell migration. Moreover, we found that IL-1R8 suppresses macrophage proliferation through p38 MAPK signaling pathway. Therefore, our study suggests that IL-1R8 is a new positive regulator for macrophage migration and suppresses macrophage proliferation.

Source: Biomedicine & Pharmacotherapy

DOI: 10.1016/j.biopha.2020.109846

Authors: Jing Guo, Xiangwen Zhan, Guiying Xu, Chuanbin Mao, Rongfei Wei

Institutions: Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Laboratory Animal Science, University of Oklahoma, University of Science and Technology Beijing

Language: English

Topic: Immune Response and Inflammation

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,000