Stereotactic radiation therapy for breast cancer in the elderly
Year: 2020
Type: article
Abstract: : The management of breast cancer in elderly women is going to be a major public health issue in a near future. The use of hypofractionated stereotactic radiotherapy is expanding but might be a priori not offered to older patients. We addressed the role of stereotactic radiotherapy (SBRT, 1–10 fractions) in elderly patients with breast cancer, in definitive, adjuvant and metastatic settings. Review of the literature. Of six series using SBRT for partial breast or breast boost irradiation and over 20 oligometastatic (brain, lung, liver, bone) SBRT series including patients aged ≥60 years old, no difference was found in term of efficacy (>80%) and toxicity (<5% G3-4) compared to the younger. Hypofractionation is also well adapted to the elderly, due to limited transportation-related fatigue. SBRT studies by age group are lacking. However, hypofractionated SBRT is particularly adapted to older patients with breast cancer, in term of efficacy and tolerability and should be encouraged rather than more morbid treatments whenever possible.
Source: Translational Cancer Research
Institutions: Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean, Centre François Baclesse, École Nationale Supérieure d'Ingénieurs de Caen, Normandie Université, Laboratoire de Physique Corpusculaire de Caen, Institut National de Physique Nucléaire et de Physique des Particules, Université de Caen Normandie
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W3003124347