IDDF2019-ABS-0129 Optimal cut-off value of fecal calprotectin for the evaluation of inflammatory bowel disease: an unsolved issue?
Year: 2019
Type: conference-paper
Abstract: Background There is variability in the fecal calprotectin (FCP) cut-off level for the prediction of inflammatory bowel disease (IBD) activity and differentiation from irritable bowel disease (IBS). We aimed to assess the status of the optimal FCP cut-off value for the evaluation of IBD. Methods We reviewed the existing literature regarding the optimal FCP cut-off level in patients with IBD for the prediction of disease activity, remission, relapse and differentiation from IBS patients. Results The study reveals the large quantitative differences in FCP cut-off levels in different study populations (from 50 to918 microgram/gram) (table 1). FCP cut-off value for the initial diagnosis of IBD or active disease status ranged from 50 to800 microgram/gram. A cut-off level of 50–250 microgram/gram differentiated patients of IBD from IBS. Cut-off level of FCP for the prediction of remission ranged from 250 to 918 microgram/gram. Cut-off value for the prediction of relapse ranged from 50 to200 microgram/gram. Variability in the cut-off level is due to the use of different test kits and different study populations. Gastrointestinal infections and chronic subclinical intestinal inflammation, may explain the higher cut-off FCP levels in underdeveloped populations. Studies have demonstrated high levels of FCP in patients with intestinal tuberculosis and chronic giardia infection. Conclusions There is a wide variation in FCP cut-off levels in the initial diagnosis of IBD as well as in follow-up post-treatment. The FCP cut-off levels vary from country to country. The FCP test requires validation of the available test kits and finding of appropriate cut-off levels for different study populations.
Source: Gut
Authors: Arya Suchismita, Ashish Jha
Institution: Indira Gandhi Institute of Medical Sciences
Language: English
Topic: Inflammatory Bowel Disease
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W3004846969