Work

Mucin-Like Domain of Ebola Virus Glycoprotein Enhances Selective Oncolytic Actions against Brain Tumors

Year: 2020

Type: article

Abstract: The Ebola virus glycoprotein contains a mucin-like domain which may play a role in immune evasion. Chimeric vesicular stomatitis viruses with the EBOV glycoprotein substituted for the VSV glycoprotein show greater safety and efficacy in targeting brain tumors in immunodeficient mice when the MLD was expressed within the EBOV glycoprotein than when EBOV lacked the mucin-like domain.

Source: Journal of Virology

DOI: 10.1128/jvi.01967-19

Authors: Xue Zhang, Tingting Zhang, John N. Davis, Andrea Marzi, Anthony M. Marchese, Michael D. Robek, Anthony N. van den Pol

Institutions: Yale University, National Institute of Allergy and Infectious Diseases, Albany Medical College

Language: English

Topic: Virus-based gene therapy research

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Cancer Institute

Awards: Vesicular stomatitis VSVrp30 selectively destroys human metastatic melanoma, Lassa-VSV targets and kills glioma, and is not neurotoxic

OpenAlex ID: W3005502995

FWCI: 1.448

Cites: 46

Cited by: 50

Related to: 10