Work

New Cyclic Depsipeptide Antibiotics, Clavariopsins A and B, Produced by an Aquatic Hyphomycetes, Clavariopsis aquatica.

Year: 2001

Type: article

Abstract: The structures of new cyclic decadepsipeptides, clavariopsins A and B, were determined to be cyclo[-(R)-2-hydroxyisovaleryl-L-pipecoyl-L-MeVal-L-Val-L-MeAsp-L-MeIle-L-MeIle-Gly L-MeVal-L-Tyr(OMe)-] and cyclo[-(R)-2-hydroxyisovaleryl-L-pipecolyl-L-Val-L-Val-L-MeAsp-L-Melle-L-MeIle-Gly-L-MeVal-L-Tyr(OMe)-], respectively, by spectroscopic analyses, especially using 2D NMR techniques. The absolute stereochemistry was elucidated by the advanced Marfey's method and chiral HPLC analysis.

Source: The Journal of Antibiotics

DOI: 10.7164/antibiotics.54.22

Authors: YOSHIHIRO SUZUKI, MAKOTO OJIKA, YOUJI SAKAGAMI, KENICHI KAIDA, RYOSUKE FUDOU, TOSHIYUKI KAMEYAMA

Institutions: Nagoya University, Ajinomoto (Japan)

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Applied Microbiology and Biotechnology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: bronze

Funder: Meijo University

OpenAlex ID: W3005771198

FWCI: 1.296

Cites:

Cited by: 27

Related to: 10