Work

Design and Synthesis Of' Some New 1h-1,2,4-triazoles of Potential Anti-inflammatory and Analgesic Activities

Year: 1994

Type: article

Abstract: The synthesized 1H-1,2,4-triazoles (7a-c, 8a-c and 9a-c), a novel class of heterocyclic compounds of potential anti-inflammatory and analgesic activities, are of interest, since they present some differences compared to the classical non-steroidal anti-inflammatory agents. The anti-inflammatory activity of all derivatives was studied in albino rats using trypan-blue and kaolin-induced edema methods. The compounds were also tested in albino mice for their analgesic activity using the hot plate and p-benzoquinone-induced writhing methods. A correlation between the structures, pharmacological actions and the calculated partition coefficients of the products was studied.

Source: Bulletin of Pharmaceutical Sciences Assiut

DOI: 10.21608/bfsa.1994.69785

Authors: Hoda Hassan, Abdel-Nasser El-Shorbagi, Nawal El-Koussi, Ahmed Abdel-Zaher

Institution: Assiut University

Language: English

Topic: Structural and Chemical Analysis of Organic and Inorganic Compounds

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W3005774360