Work

Genomic Characterization of Neisseria gonorrhoeae Strains from 2016 U.S. Sentinel Surveillance Displaying Reduced Susceptibility to Azithromycin

Year: 2020

Type: article

Abstract: In 2016, the proportion of Neisseria gonorrhoeae isolates with reduced susceptibility to azithromycin rose to 3.6%. A phylogenetic analysis of 334 N. gonorrhoeae isolates collected in 2016 revealed a single, geographically diverse lineage of isolates with MICs of 2 to 16 μg/ml that carried a mosaic-like mtr locus, whereas the majority of isolates with MICs of ≥16 μg/ml appeared sporadically and carried 23S rRNA mutations.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.02420-19

Authors: Matthew W. Schmerer, A. Jeanine Abrams, Sandra Seby, Jesse C. Thomas, John Cartee, Sean Lucking, Eshaw Vidyaprakash, Cau D. Pham, Samera Sharpe, Kevin Pettus, Sancta B. St. Cyr, Elizabeth A. Torrone, Ellen N. Kersh, Antimicrobial-Resistant Neisseria gonorrhoeae Working Group, Kim M. Gernert, Antimicrobial-Resistant Neisseria gonorrhoeae Working Group, Catherine Dominguez, Catherine Dominguez, Sopheay Hun, Olusegun O. Soge, A. Christian Whelen, Pamela O'Brien, Alesia Harvey, Tara Henning

Institutions: Centers for Disease Control and Prevention, Oak Ridge Institute for Science and Education

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Centers for Disease Control and Prevention

OpenAlex ID: W3007194635

FWCI: 1.084

Cites: 16

Cited by: 20

Related to: 10