Work

Comparison of BRCA versus non-BRCA germline mutations and associated somatic mutation profiles in patients with unselected breast cancer

Year: 2020

Type: article

Study design: Observational Study

Abstract: were different among the three groups. By investigating all breast and ovarian cancer-related genes listed in the US genetic guidelines, we identified 15 cancer susceptibility genes frequently mutated in the germline of our population and must be included in cancer predisposition screening. Our study contributed a better understanding of the tumor characteristics of patients with LP/P germline mutations.

Source: Aging

DOI: 10.18632/aging.102783

Authors: Bo Chen, Guochun Zhang, Xuerui Li, Chongyang Ren, Yulei Wang, Kai Li, Hsiaopei Mok, Li Cao, Lingzhu Wen, Minghan Jia, Cheukfai Li, Liping Guo, Guangnan Wei, Jiali Lin, Yingzi Li, Yuchen Zhang, Han Han-Zhang, Jing Liu, Analyn Lizaso, Ning Liao

Institutions: Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital, South China University of Technology, Southern Medical University, Burning Rock Biotech (China)

Language: English

Topic: BRCA gene mutations in cancer

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Natural Science Foundation of China, Natural Science Foundation of Guangdong Province, Guangzhou Municipal Science and Technology Project, Fundamental Research Funds for the Central Universities

Awards: G1069826922, G2028010562, G3525361785, G4201763712, G4385065908, G4715147254, G5066849736, G5306076784, G6099411151, G6282535039, G7320445509

OpenAlex ID: W3008614031

FWCI: 4.101

Cites: 43

Cited by: 54

Related to: 10